Okay, does nobody see the problem with this:
Nasus' Siphoning Strike and Fury of the Sands both apply spell vamp. I'm not going to say it's easy to pull off, but I will say it is a game ending monster.

If you don't allow me to tell you:
Runes: AD, Armor, MR/Level, Spell Vamp
Spells: Smite and Flash/ Cleanse
Masteries: 6/11/13
(CDR and minion damage; health/level, minion reduction and damage, armor, health; mana regen, 1 point move speed, summoner cooldowns, mana/level, lifesteal/spellvamp)

End game there should be a Hextech Gunblade among your items.... Read More

When I play teemo (at least when I finish my runes for him), I walk in with 5% lifesteal, 5% spell vamp, and then another 10% lifesteal from vampiric scepter. I end with roughly 400 ap, 230 ad plus 42 magic damage each hit, 4% per hit, magic resist reduction each hit, slow 35% each hit, heal 25% of the magic damage I deal, and heal 20% of the physical damage I deal. I cut through tanks like they have no health or defense at all. My shrooms don't do nearly as much as an AP teemo, but not far from it. I still get enormous damage output from basic attacks like AD teemo, not quite as much flat... Read More